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Special Guest Seminar – Josef Penninger

24.04.2014
Topic

How to license innate immunity to kill cancer metastases.

Speaker

Josef Penninger, Institute of Molecular Biotechnology, Vienna

Host

Andrew Pospisilik

Room

Main Lecture Hall


http://www.ie-freiburg.mpg.de/401957...osef_Penninger

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Special Guest Seminar - Alexander Tarakhovsky

08.05.2014
Topic

Control of gene expression by histone mimics

Speaker

Alexander Tarakhovsky, Rockefeller University, USA

Host

Philipp Rauf

Room

Main Lecture Hall


http://www.ie-freiburg.mpg.de/401959...er_Tarakhovsky

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Special Guest Seminar - Xiaowei Zhunang

22.05.2014 13:00 - 14:00 sine tempore
Topic

Bioimaging at the nanoscale: single-molecule and super-resolution fluorescence microscopy.

Speaker

Xiaowei Zhunang, Harvard University, Cambridge, MA, USA

Host

Asifa Akhtar

Room

Main Lecture Hall


http://www.ie-freiburg.mpg.de/401960...iaowei_Zhunang

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First shark genome decoded

Genome of the elephant shark provides new insights into immunity and bone formation
January 08, 2014
An international team of researchers, including scientists of the Max Planck Institute of Immunobiology and Epigenetics, has sequenced and analysed the genome of the elephant shark. Comparison of the elephant shark genome with human and other vertebrate genomes has revealed why the skeleton of sharks is made up largely of cartilage and not bone like the human skeleton and that the immune system of the shark is much simpler than that of humans. The findings of Byrappa Venkatesh and his coworkers are published in the latest issue of the scientific journal, Nature.

Zoom Image The immune system of the elephant shark is simpler than many other vertebrates studied so far. The present studies also... [more]

© Fir0002/Flagstaffotos


An unexpected finding of the immune system analysis was that sharks appear to lack special types of so-called T-helper lymphocytes, that – until now – were considered to be essential for defence against viral/bacterial infections and preventing autoimmune reactions such as diabetes and rheumatoid arthritis in vertebrates.
Despite this seemingly primitive organization of the immune system, sharks exhibit robust immune defences and are long-lived. “The structure of the immune system of the elephant shark is very different from mammals,” said Thomas Boehm, co-author and director at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. “It is obvious that sharks can efficiently deal with all kinds of infections without this particular cell type. This indicates that nature can come up with different solutions to the same problem,” stated Boehm.
What happens when T-helper cells are being destroyed can be observed in AIDS patients, who succumb to viral and bacterial infections. Up to now, it was assumed that cells are essential for an immune system. The new results are challenging this long-held notion and open up an unprecedented avenue towards the development of non-intuitive strategies to modulate the immune functions of humans.
The researchers also investigated why cartilaginous fishes, including the elephant shark, are unable to replace cartilage with bone like humans and other bony vertebrates. Genome analysis was able to highlight a family of genes that are absent in sharks but present in all bony vertebrates and are critical for bone formation. When the researchers inactivated these genes in bony fishes such as the zebrafish, calcification did not occur. This finding is a strong indication that the investigated gene family could be a starting point for a better understanding of bone diseases such as osteoporosis.
In addition, the study revealed that the elephant shark genome is the slowest evolving among all vertebrates. The elephant shark even beats the coelacanth, also called “the living fossil”, that has recently been shown to evolve extremely slowly. Therefore, the elephant shark is probably the best proxy for the ancestor of all jawed-vertebrates that became extinct a long time ago.
Cartilaginous fishes (comprising sharks, rays, skates and chimaeras) are the oldest living group of jawed-vertebrates that diverged from bony vertebrates about 450 million years ago. The elephant shark (Callorhinchus milii) is a chimaera that inhabits temperate waters of the continental shelves off southern Australia and New Zealand, at depths of 200 to 500 meters. From approximately 1,000 species of cartilaginous fishes, elephant shark was chosen as a model because of its relatively compact genome which is one third the size of the human genome.
The elephant shark genome project was funded mainly by the National Institutes of Health (NIH), USA. It is a collaborative effort of scientists from 12 international institutions, including the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg, Germany. Viruses, bacteria and other parasites are a continuous threat to all living beings. Therefore, most of them possess elaborate defence strategies to combat these unwanted intruders. At the Max Planck Institute of Immunobiology and Epigenetics, Thomas Boehm studies the evolution of the immune system and its development and function during lifetime of animals. For his fundamental work on development, differentiation and evolution of immune systems, Thomas Boehm is awarded the prestigious Ernst Jung Award for Medicine 2014.

JF/BA

http://www.ie-freiburg.mpg.de/368063...96371?c=723600

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Special Event - Digitale Welten - Douglas Rushkoff: Present Shock Dienstag, 6. Mai 2014, 20:15 Douglas Rushkoff, a leading media theorist, has been an authority on the intersection of technology and culture sin- ce before the word “google” was anything more than baby talk. Back in 1992, he predicted the coming centrality of the internet; he coined the term viral media in 1994 and fore- casted the collapse of the dotcom bubble in 1997. Racking up a total of 12 bestselling books, Rushkoff shaped our understanding of digital spaces. In his new effort, „Present Shock: When Everything Happens Now“, Rushkoff intro- duces the phenomenon of presentism, or – since most of us are finding it hard to adapt – present shock. The author argues that the future is now and that we no longer own a commanding sense of goals or of a direction at all. We live in this always-on “now,” where the priorities of this moment seem to be everything. Douglas Rushkoff will be present via video conference and engage in a conversation with Daniel Fetzner, currently a professor for Design and Artistic Research at Hochschule Offenburg. Other German -American Institutes will also broadcast our event. Eintritt frei With: Orange Press Verlag, Grünhof, Landeszentrale für politische Bildung, Colloquium politicum

Veranstaltungsort* Carl-Schurz-Haus, Konferenzraum, Eisenbahnstr. 62

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Referent:	Prof. Maarten van Lohuizen, The Netherlands Cancer Institute, Amsterdam
Thema:	Histone-lysine methyltransferase Ezh2 inhibition in an in vivo model for Glioblastoma
Beschreibung:	SFB 992 Colloquium - Medical Epigenetics "From basic mechanisms to clinical applications"
Ausführliche Beschreibung:
Veranstalter:	SFB 992 Anschrift: SFB 992 "Medizinische Epigenetik (MEDEP) Von grundlegenden Mechanismen zu klinischen Anwendungen" Breisacher Straße 66 79106 Freiburg Telefon: +49 761 270 63100 Email: roland.schuele@uniklinik-freiburg.de http://www.sfb992.uni-freiburg.de/
Weitere Infos:	http://www.sfb992.uni-freiburg.de
Ansprechpartner:	Sekretariat des SFB 992
Kontakt:	Tel: 0761-270-63981 Email: sfb992@uniklinik-freiburg.de
Zeit:	06.05.2014 15:00
Ort:	ZKF, Breisacherstr. 66, 1.OG, großer Seminarraum

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Referent:	Prof. Dr. med. Joachim Bauer, Oberarzt der Klinik für Psychosomatische Medizin und Psychotherapie, Uniklinik Freiburg
Thema:	Exzellenter Psychologe und Pionier der Psychosomatischen Medizin: Der unbekannte Charles Darwin
Beschreibung:	Interdisziplinäres Kolloquium Sommersemester 2014
Ausführliche Beschreibung:	Für Mitglieder und Hörer aller Fakultäten sowie Gäste jeweils dienstags von 18.00 c. t. bis 20.00 Uhr Ort: Auditorium Maximum (gegenüber Theater) Hörsaal Kollegiengebäude II - Platz der Alten Synagoge
Veranstalter:	Abteilung für Psychosomatische Medizin und Psychotherapie Anschrift: Zentrum für Psychische Erkrankungen (Department) Klinik für Psychosomatische Medizin und Psychotherapie Hauptstrasse 8 79104 Freiburg Telefon: +49 / 761 / 270-68060 Fax: +49 / 761 / 270-68850
Weitere Infos:	http://www.uniklinik-freiburg.de/psy...olloquium.html
Ansprechpartner:	Ute Kato
Kontakt:	Tel: (0761) 270-66850 Fax: (0761) 270-68850 Email: Ute.Kato@uniklinik-freiburg.de
Zeit:	06.05.2014 18:15
Ort:	Auditorium Maximum, Hörsaal Kollegiengebäude II

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Psychosomatisches Dienstagskolloquium „Seele–Körper–Geist“

Dienstag / 18.15 Uhr / Audimax, KG I
Interdisziplinäres Kolloquium Sommersemester 2014

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Dienstag 29.04.14	Dr. phil. Dipl. Psych. Elmar Reuter, (Psychoonkologe, Olpe) Krankheit als Krise und Wendepunkt: Psychotherapeutisches Arbeiten mit Krebskranken
Dienstag 06.05.14	Prof. Joachim Bauer, (Uniklinik Freiburg) Exzellenter Psychologe und Pionier der psychosomatischen Medizin: Der unbekannte Charles Darwin
Dienstag 13.05.14	Prof. Dr. Volker A. Coenen, (Uniklinik Freiburg) Tiefe Hirnstimulation zur Behandlung der therapierefraktären Depression
Dienstag 20.05.14	Prof. Dr. jur. Christian Pfeiffer, (Kriminologisches Forschungsinstitut, Hannover) Jungen in der Krise – Forschungsbefunde und Konsequenzen
Dienstag 27.05.14	Prof. Dr. rer. Stefan Kölsch, (FU Berlin) When Music meets Brain: Das menschliche Gehirn, ein musikalische Organ
Dienstag 03.06.14	Prof. Dr. Joachim Weis, (Tumorbiologie Freiburg) Patientenkompetenz. Lebensbedrohliche Erkrankungen erfolgreich bewältigen?
Dienstag 24.06.14	Prof. Dr. Urs Fischbacher, (Universität Konstanz) „Soll ich einem Piloten Geld ausleihen?“ Über Vertrauen und Fairness
Dienstag 01.07.14	Ray Austin (Gesang, Gitarre), Michael Zumstein (Mandoline Gitarre), Hubert Huber (Bass) (alle Freiburg) Songs als Botschafter und Spiegel der Menschlichkeit – in memoriam Pete Seege & Woodie Guthrie
Dienstag 08.07.14	Prof. Dr. Michael Falkenstein, (TU Dortmund) Die Wirkung von Arbeit auf die mentale und körperliche Gesundheit von älteren Beschäftigten
Dienstag 15.07.14	Prof. Dr. Christoph Herrmann-Lingen, (Universitätsmedizin Göttingen) Was die Psychosomatische Medizin im Innersten zusammenhält
Dienstag 22.07.14	Prof. Dr. Michael Wirsching (Uniklinik Freiburg) Macht Stadtluft krank? – Teil II / Vortrag mit Podiumsdiskussion

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Lustige Bilderbücher

Felizitas Lacher zeigt am Mittwoch, 28. Mai, 16 Uhr für Kinder von 3 bis 5 Jahren lustige und spannende Bilderbücher in der Kinder- und Jugendbibliothek, Münsterplatz 17. Der Eintritt ist frei